Jacque Duncan, M.D.

Beckman Vision Center, University of California - San Francisco

Project:  High resolution retinal imaging in patients with retinal degenerations
Summary: Dr. Duncan and her team will correlate the images of retinal structure produced by the Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO) with standard measures of retinal structure created with an instrument known as Optical Coherence Tomography (OCT).  OCT images provide information about retinal structure in cross-section, while AOSLO gives en face images of individual cones.  By combining these two techniques Dr. Duncan hopes to learn more about how changes in cone structure relate to vision loss in patients with retinal degenerations.  In addition, Dr. Duncan will correlate the images of cone structure obtained using AOSLO with standard clinical measures of retinal function used in Ophthalmology clinics, including visual acuity, automated perimetry, fundus photography including fundus autofluorescence and multifocal electroretinography (mfERG), to learn how well the cones work or are able to see.