Kristina Narfstom, D.V.M.

Dept of Veterinary Medicine, University of Missouri

Project: Research in large animal models of retinal degeneration with an emphasis on proof-of-concept
Summary:  Dr. Narfstrom is investigating the implantation of light-sensing microchips in the retinas of animal models. The chips contain thousands of miniature solar cells that turn light into electrical current and early studies show that they may have even further benefits for people with RP in that they seem to actually slow progression of the disease.  In addition, Dr. Narfstrom hopes to use gene replacement therapy to restore sight in the same animal model. Success with animal models would pave the way for using this approach in people with RP.  Narfstrom already has had success using gene therapy to restore sight to French sheepdogs that suffer from another inherited retinal disorder. The dogs, called Briards, are born with night blindness and poor daylight vision that get progressively worse with age.